Slc19a1 - solute carrier family 19 (folate transporter), member 1 Gene

Also Known as RFC; RFC1; RFC-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20509

Summary

Enables folic acid transmembrane transporter activity and methotrexate transmembrane transporter activity. Involved in folate import across plasma membrane and methotrexate transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cleft lip; dextro-looped transposition of the great arteries; hematologic cancer; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc19a1 Products (2)

mRNA Protein Name
NM_001199271.1 NP_001186200.1 reduced folate transporter
NM_031196.3 NP_112473.1 reduced folate transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables cyclic-GMP-AMP transmembrane transporter activity IDA
IDA: Inferred from direct assay
31511694 MGI
enables folic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
9111015 MGI
enables methotrexate transmembrane transporter activity IDA
IDA: Inferred from direct assay
9748272 MGI
Biological Process GO Annotation Evidence References Source
NOT involved in cyclic-GMP-AMP transmembrane import across plasma membrane IDA
IDA: Inferred from direct assay
31511694 MGI
involved in folate import across plasma membrane IDA
IDA: Inferred from direct assay
9111015 MGI
involved in folate transmembrane transport IDA
IDA: Inferred from direct assay
9111015 MGI
involved in methotrexate transport IDA
IDA: Inferred from direct assay
9748272 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10787414 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

reduced folate transporter

  • IFC-1

  • folate transporter 1

  • intestinal folate carrier 1

  • intestinal folate carrier protein

  • plasma membrane folate antiporter SLC19A1

  • reduced folate carrier 1

  • solute carrier family 19 (sodium/hydrogen exchanger), member 1

  • solute carrier family 19 memb

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13047 SLC19A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc19a1 NCBI NCBI:6573