Slc1a6 - solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 Gene

Also Known as EAAT4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20513

Summary

Enables L-glutamate transmembrane transporter activity. Acts upstream of or within L-glutamate transmembrane transport and regulation of membrane potential. Located in Golgi apparatus; glutamatergic synapse; and membrane. Is integral component of presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a6 Products (1)

mRNA Protein Name
NM_009200.3 NP_033226.1 excitatory amino acid transporter 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glutamate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
14715943 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within L-glutamate transmembrane transport IMP
IMP: Inferred from mutant phenotype
14715943 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
14715943 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
14715943 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
20231455 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23049999 MGI
located in membrane IDA
IDA: Inferred from direct assay
20231455 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
23049999 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

excitatory amino acid transporter 4

  • high-affinity neuronal glutamate transporter

  • sodium-dependent glutamate/aspartate transporter

  • solute carrier family 1, member 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13057 SLC1A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc1a6 NCBI NCBI:6511