Slfn1 - schlafen 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20555

Summary

Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; negative regulation of T cell proliferation; and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; oviduct; and spleen. Orthologous to human SLFN12 (schlafen family member 12) and SLFN12L (schlafen family member 12 like). [provided by Alliance of Genome Resources, Apr 2022]

Slfn1 Products (2)

mRNA Protein Name
NM_011407.2 NP_035537.1 schlafen 1
NM_011407.2 NP_035537.1 schlafen 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18373498 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
18373498 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
9846487 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
15946944 MGI
acts upstream of or within negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
18373498 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
9846487 MGI
acts upstream of or within negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15946944 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18373498 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
9846487 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18373498 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18373498 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

schlafen 1

  • Schlafen family member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13363 SLFN11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13364 SLFN12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13365 SLFN12L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13366 SLFN13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13367 SLFN14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown