Smpd2 - sphingomyelin phosphodiesterase 2, neutral Gene

Also Known as nSMase; nSMase1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20598

Summary

This gene encodes a protein with similarity to the human nSMase1 protein. In humans, the nSMase1 protein was initially identified as a sphingomyelinase based on sequence similarity between Bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]

Smpd2 Products (1)

mRNA Protein Name
NM_009213.2 NP_033239.1 sphingomyelin phosphodiesterase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
9520418 MGI
enables sphingomyelin phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
15764706 MGI
Biological Process GO Annotation Evidence References Source
involved in ceramide metabolic process IDA
IDA: Inferred from direct assay
9520418 MGI
involved in sphingomyelin catabolic process IDA
IDA: Inferred from direct assay
9520418 MGI
acts upstream of or within sphingomyelin catabolic process IMP
IMP: Inferred from mutant phenotype
23973266 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
9520418 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingomyelin phosphodiesterase 2

  • N-SMase

  • lyso-PAF-PLC

  • lyso-platelet-activating factor-phospholipase C

  • neutral sphingomyelinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134505 Avicin G Inhibitor / Unkown
HY-RS13448 SMPD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smpd2 NCBI NCBI:6610