Smpd2 - sphingomyelin phosphodiesterase 2, neutral Gene

Mus musculus

Also known as nSMase; nSMase1

Gene ID: 20598 | Gene type: protein coding

About Smpd2

Summary

This gene encodes a protein with similarity to the human nSMase1 protein. In humans, the nSMase1 protein was initially identified as a sphingomyelinase based on sequence similarity between Bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]

Smpd2 Products(1)

mRNA	Protein	Name
NM_009213.2	NP_033239.1	sphingomyelin phosphodiesterase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sphingomyelin phosphodiesterase activity	IDA IDA: Inferred from direct assay	9520418	MGI
enables sphingomyelin phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	15764706	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	9520418	MGI
involved in sphingomyelin catabolic process	IDA IDA: Inferred from direct assay	9520418	MGI
acts upstream of or within sphingomyelin catabolic process	IMP IMP: Inferred from mutant phenotype	23973266	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	9520418	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sphingomyelin phosphodiesterase 2

N-SMase	lyso-PAF-PLC
lyso-platelet-activating factor-phospholipase C	neutral sphingomyelinase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134505	Avicin G	Inhibitor	/	Unkown
HY-RS13448	SMPD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smpd2	NCBI	NCBI:6610

Name
Email *

	Sorry, but the email address you supplied was invalid.