Sox11 - SRY (sex determining region Y)-box 11 Gene

Also Known as end1; 1110038H03Rik; 6230403H02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20666

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; nervous system development; and regulation of gene expression. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 9. Orthologous to human SOX11 (SRY-box transcription factor 11). [provided by Alliance of Genome Resources, Apr 2022]

Sox11 Products (1)

mRNA Protein Name
NM_009234.6 NP_033260.4 transcription factor SOX-11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
18403418 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18505825 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
21527504 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19808959 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18505825 MGI
Biological Process GO Annotation Evidence References Source
involved in closure of optic fissure IMP
IMP: Inferred from mutant phenotype
18423449 MGI
involved in cornea development in camera-type eye IMP
IMP: Inferred from mutant phenotype
18423449 MGI
involved in embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in eyelid development in camera-type eye IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in glial cell development IMP
IMP: Inferred from mutant phenotype
20147379 MGI
involved in glial cell proliferation IMP
IMP: Inferred from mutant phenotype
20147379 MGI
involved in hard palate development IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in lens morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
18423449 MGI
involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19808959 MGI
involved in negative regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
19808959 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19808959 MGI
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
20596238 MGI
involved in neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
20646169 MGI
involved in noradrenergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
20147379 MGI
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
18423449 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21527504 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18423449 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19808959 MGI
involved in positive regulation of hippo signaling IMP
IMP: Inferred from mutant phenotype
20596238 MGI
involved in positive regulation of hormone secretion IMP
IMP: Inferred from mutant phenotype
21527504 MGI
involved in positive regulation of lens epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18423449 MGI
involved in positive regulation of neurogenesis IDA
IDA: Inferred from direct assay
19490090 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
19490090 MGI
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
19808959 MGI
involved in positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18403418 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
20847309 MGI
involved in soft palate development IMP
IMP: Inferred from mutant phenotype
15254231 MGI
involved in spinal cord development IMP
IMP: Inferred from mutant phenotype
20646169 MGI
involved in sympathetic nervous system development IMP
IMP: Inferred from mutant phenotype
20147379 MGI
involved in ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
15254231 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15456859 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-11

  • SRY-box containing gene 11

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13584 SOX11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21764 Sox11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28281 Sox11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox11 NCBI NCBI:6664