2. Gene
  3. Sptan1 - spectrin alpha, non-erythrocytic 1 Gene

Sptan1 - spectrin alpha, non-erythrocytic 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Spna2; Spna-2; 2610027H02Rik

Gene ID: 20740 | Gene type: protein coding

About Sptan1

Summary

Enables spectrin binding activity. Predicted to be involved in actin Cytoskeleton reorganization. Predicted to act upstream of or within actin filament capping. Located in several cellular components, including cuticular plate; fascia adherens; and lateral plasma membrane. Is active in paranodal junction. Is expressed in gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 5. Orthologous to human SPTAN1 (spectrin alpha, non-erythrocytic 1). [provided by Alliance of Genome Resources, Apr 2022]

Sptan1 Products(4)

mRNA Protein Name
NM_001177667.1 NP_001171138.1 spectrin alpha chain, non-erythrocytic 1 isoform 2
NM_001177668.1 NP_001171139.1 spectrin alpha chain, non-erythrocytic 1 isoform 3
NM_001309460.1 NP_001296389.1 spectrin alpha chain, non-erythrocytic 1 isoform 4
NM_001369325.1 NP_001356254.1 spectrin alpha chain, non-erythrocytic 1 isoform 5
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18796539 MGI
enables spectrin binding IDA
IDA: Inferred from direct assay
18796539 MGI
enables spectrin binding IPI
IPI: Inferred from physical interaction
18796539 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
15247274 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
located in cuticular plate IDA
IDA: Inferred from direct assay
18796539 MGI
located in fascia adherens IDA
IDA: Inferred from direct assay
16481394 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
18796539 MGI
located in membrane IDA
IDA: Inferred from direct assay
18723693 MGI
is active in paranodal junction IDA
IDA: Inferred from direct assay
16687515 MGI
located in paranode region of axon IDA
IDA: Inferred from direct assay
16551741 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spectrin alpha chain, non-erythrocytic 1

alpha-II spectrin

alpha-spectrin 2, brain

alphaII-spectrin

fodrin alpha chain

spectrin alpha chain, brain

spectrin, non-erythroid alpha chain

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13730 SPTAN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sptan1 NCBI NCBI:6709