Sptb - spectrin beta, erythrocytic Gene

Also Known as ja; Spnb1; Gm1301; Spnb-1; jaundiced; mKIAA4219; D330027P03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20741

Summary

Enables actin filament binding activity. Acts upstream of or within hemopoiesis; plasma membrane organization; and porphyrin-containing compound biosynthetic process. Located in cortical cytoskeleton; plasma membrane; and spectrin-associated Cytoskeleton. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 2. Orthologous to human SPTB (spectrin beta, erythrocytic). [provided by Alliance of Genome Resources, Apr 2022]

Sptb Products (1)

mRNA Protein Name
NM_013675.3 NP_038703.3 spectrin beta chain, erythrocytic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
20585040 MGI
enables actin filament binding IDA
IDA: Inferred from direct assay
20585040 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20585040 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
9373273 MGI
acts upstream of or within plasma membrane organization IMP
IMP: Inferred from mutant phenotype
9373263 MGI
acts upstream of or within porphyrin-containing compound biosynthetic process IMP
IMP: Inferred from mutant phenotype
658175 MGI
Cellular Component GO Annotation Evidence References Source
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
located in membrane IDA
IDA: Inferred from direct assay
18723693 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14627610 MGI
located in spectrin-associated cytoskeleton IMP
IMP: Inferred from mutant phenotype
6234993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spectrin beta chain, erythrocytic

  • beta-I spectrin

  • beta-spectrin 1

  • brain erythroid spectrin (235E)

  • spectrin R

  • spectrin beta 1

  • spectrin beta chain, erythrocyte

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13731 SPTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sptb NCBI NCBI:6710