Ccdc40 - coiled-coil domain containing 40 Gene

Also Known as B930008I02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 207607

Summary

Involved in epithelial cilium movement involved in determination of left/right asymmetry; lung development; and protein localization to cilium. Acts upstream of or within axoneme assembly and determination of left/right symmetry. Located in cilium and cytoplasm. Is active in motile cilium. Is expressed in several structures, including central nervous system; node; olfactory epithelium; and respiratory system. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 15. Orthologous to human CCDC40 (coiled-coil domain containing 40). [provided by Alliance of Genome Resources, Apr 2022]

Ccdc40 Products (5)

mRNA Protein Name
NM_001364767.2 NP_001351696.1 coiled-coil domain-containing protein 40 isoform 1
NM_001408391.1 NP_001395320.1 coiled-coil domain-containing protein 40 isoform 2
NM_001408393.1 NP_001395322.1 coiled-coil domain-containing protein 40 isoform 3
NM_001408394.1 NP_001395323.1 coiled-coil domain-containing protein 40 isoform 4
NM_001408395.1 NP_001395324.1 coiled-coil domain-containing protein 40 isoform 5

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within axoneme assembly IMP
IMP: Inferred from mutant phenotype
26387594 MGI
involved in cilium movement IMP
IMP: Inferred from mutant phenotype
21131974 MGI
acts upstream of or within determination of left/right symmetry IGI
IGI: Inferred from genetic interaction
28182636 MGI
involved in epithelial cilium movement involved in determination of left/right asymmetry IMP
IMP: Inferred from mutant phenotype
21131974 MGI
involved in lung development IMP
IMP: Inferred from mutant phenotype
21131974 MGI
involved in protein localization to cilium IMP
IMP: Inferred from mutant phenotype
26387594 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
21131974 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21131974 MGI
is active in motile cilium IDA
IDA: Inferred from direct assay
26387594 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coiled-coil domain-containing protein 40

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02046 CCDC40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccdc40 NCBI NCBI:55036