Shroom4 - shroom family member 4 Gene

Also Known as Gm724; Shrm4; D430043L16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208431

Summary

Enables actin filament binding activity and Myosin II binding activity. Acts upstream of or within actin filament organization. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and stress fiber. Colocalizes with cortical actin Cytoskeleton. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in Stocco Dos Santos type X-linked intellectual disability. Orthologous to human SHROOM4 (shroom family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Shroom4 Products (3)

mRNA Protein Name
NM_001040459.2 NP_001035549.1 protein Shroom4 isoform 1
NM_001313764.1 NP_001300693.1 protein Shroom4 isoform 2
NM_001313765.1 NP_001300694.1 protein Shroom4 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
17009331 MGI
enables myosin II binding IDA
IDA: Inferred from direct assay
17009331 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament organization IDA
IDA: Inferred from direct assay
17009331 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
17009331 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17009331 MGI
located in basal plasma membrane IDA
IDA: Inferred from direct assay
17009331 MGI
colocalizes with cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
16684770 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17009331 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
17009331 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Shroom4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12887 SHROOM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shroom4 NCBI NCBI:57477