Sgms1 - sphingomyelin synthase 1 Gene

Also Known as Mob; Sms1; Sor1; Tmem23; 9530058O11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208449

Summary

Enables ceramide phosphoethanolamine synthase activity and sphingomyelin synthase activity. Involved in sphingomyelin biosynthetic process. Acts upstream of or within ceramide biosynthetic process and negative regulation of extrinsic apoptotic signaling pathway. Predicted to be located in Golgi trans cisterna. Predicted to be integral component of Golgi membrane; integral component of endoplasmic reticulum membrane; and integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; limb; and respiratory system. Orthologous to human SGMS1 (sphingomyelin synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sgms1 Products (4)

mRNA Protein Name
NM_001168525.1 NP_001161997.1 phosphatidylcholine:ceramide cholinephosphotransferase 1
NM_001168526.1 NP_001161998.1 phosphatidylcholine:ceramide cholinephosphotransferase 1
NM_001362423.1 NP_001349352.1 phosphatidylcholine:ceramide cholinephosphotransferase 1
NM_144792.5 NP_659041.3 phosphatidylcholine:ceramide cholinephosphotransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ceramide phosphoethanolamine synthase activity IMP
IMP: Inferred from mutant phenotype
25605874 MGI
enables sphingomyelin synthase activity IDA
IDA: Inferred from direct assay
27892528 MGI
enables sphingomyelin synthase activity IMP
IMP: Inferred from mutant phenotype
14976195 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
25605874 MGI
involved in sphingomyelin biosynthetic process IMP
IMP: Inferred from mutant phenotype
27892528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylcholine:ceramide cholinephosphotransferase 1

  • protein Mob

  • transmembrane protein 23

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12805 SGMS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgms1 NCBI NCBI:259230