Tmem63a - transmembrane protein 63a Gene

Also Known as Tmem64a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208795

Summary

Enables mechanosensitive ion channel activity and osmolarity-sensing cation channel activity. Predicted to act upstream of or within ion transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human TMEM63A (transmembrane protein 63A). [provided by Alliance of Genome Resources, Apr 2022]

Tmem63a Products (1)

mRNA Protein Name
NM_144794.2 NP_659043.1 CSC1-like protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mechanosensitive monoatomic ion channel activity IDA
IDA: Inferred from direct assay
30382938 MGI
enables osmolarity-sensing monoatomic cation channel activity IDA
IDA: Inferred from direct assay
27045885 MGI
Biological Process GO Annotation Evidence References Source
involved in surfactant secretion IMP
IMP: Inferred from mutant phenotype
38127458 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
27045885 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CSC1-like protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14732 TMEM63A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmem63a NCBI NCBI:9725