Abcc8 - ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Gene

Mus musculus

Also known as Sur; SUR1; D930031B21Rik

Gene ID: 20927 | Gene type: protein coding

About Abcc8

Summary

Predicted to enable ATPase-coupled cation transmembrane transporter activity; Potassium Channel activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in plasma membrane. Is expressed in cerebral cortex; foregut-midgut junction; heart ventricle; and retina inner nuclear layer. Used to study hyperinsulinemic hypoglycemia and transient neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]

Abcc8 Products(5)

mRNA	Protein	Name
NM_001357538.2	NP_001344467.1	ATP-binding cassette sub-family C member 8 isoform 2
NM_001403104.1	NP_001390033.1	ATP-binding cassette sub-family C member 8 isoform 3
NM_001403109.1	NP_001390038.1	ATP-binding cassette sub-family C member 8 isoform 4
NM_001403110.1	NP_001390039.1	ATP-binding cassette sub-family C member 8 isoform 5
NM_011510.4	NP_035640.2	ATP-binding cassette sub-family C member 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	7502040	MGI
enables ATP binding	IDA IDA: Inferred from direct assay	7502040	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	23624089	MGI
acts upstream of or within cellular response to nutrient levels	IMP IMP: Inferred from mutant phenotype	23624089	MGI
acts upstream of or within glutamate secretion, neurotransmission	IGI IGI: Inferred from genetic interaction	17883401	MGI
involved in negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	25771886	MGI
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	16924481	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	17883401	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	16924481	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	7502040	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16085792	MGI
is active in plasma membrane	IGI IGI: Inferred from genetic interaction	7502040	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17883401	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family C member 8

sulfonylurea receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00066	ABCC8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcc8	NCBI	NCBI:6833

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