Abcc8 - ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Gene

Also Known as Sur; SUR1; D930031B21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20927

Summary

Predicted to enable ATPase-coupled cation transmembrane transporter activity; Potassium Channel activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in plasma membrane. Is expressed in cerebral cortex; foregut-midgut junction; heart ventricle; and retina inner nuclear layer. Used to study hyperinsulinemic hypoglycemia and transient neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]

Abcc8 Products (5)

mRNA Protein Name
NM_001357538.2 NP_001344467.1 ATP-binding cassette sub-family C member 8 isoform 2
NM_001403104.1 NP_001390033.1 ATP-binding cassette sub-family C member 8 isoform 3
NM_001403109.1 NP_001390038.1 ATP-binding cassette sub-family C member 8 isoform 4
NM_001403110.1 NP_001390039.1 ATP-binding cassette sub-family C member 8 isoform 5
NM_011510.4 NP_035640.2 ATP-binding cassette sub-family C member 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
7502040 MGI
enables ATP binding IDA
IDA: Inferred from direct assay
7502040 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within action potential IMP
IMP: Inferred from mutant phenotype
23624089 MGI
acts upstream of or within cellular response to nutrient levels IMP
IMP: Inferred from mutant phenotype
23624089 MGI
acts upstream of or within glutamate secretion, neurotransmission IGI
IGI: Inferred from genetic interaction
17883401 MGI
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
25771886 MGI
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
16924481 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
17883401 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
16924481 MGI
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
7502040 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16085792 MGI
is active in plasma membrane IGI
IGI: Inferred from genetic interaction
7502040 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17883401 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 8

  • sulfonylurea receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00066 ABCC8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc8 NCBI NCBI:6833