Hsh2d - hematopoietic SH2 domain containing Gene

Also Known as ALX; Hsh2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 209488

Summary

Enables protein-macromolecule adaptor activity. Acts upstream of or within T cell activation; negative regulation of B cell apoptotic process; and negative regulation of mitochondrial depolarization. Located in cytosol and mitochondrion. Is expressed in spleen and thymus. Orthologous to human HSH2D (hematopoietic SH2 domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Hsh2d Products (1)

mRNA Protein Name
NM_197944.1 NP_922935.1 hematopoietic SH2 domain-containing protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
12960172 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell activation IDA
IDA: Inferred from direct assay
12960172 MGI
acts upstream of or within negative regulation of B cell apoptotic process IDA
IDA: Inferred from direct assay
15569688 MGI
acts upstream of or within negative regulation of mitochondrial depolarization IDA
IDA: Inferred from direct assay
15569688 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15569688 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
15569688 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hematopoietic SH2 domain-containing protein

  • adaptor in lymphocytes of unknown function X

  • adaptor protein ALx2

  • hematopoietic SH2 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06414 HSH2D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsh2d NCBI NCBI:84941