Tbc1d4 - TBC1 domain family, member 4 Gene

Also Known as As160; A930035N22; 5930406J04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 210789

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including activation of GTPase activity; intracellular protein transport; and negative regulation of vesicle fusion. Predicted to act upstream of or within cellular response to Insulin stimulus. Predicted to be located in cytosol and vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and respiratory system. Human ortholog(s) of this gene implicated in acanthosis nigricans. Orthologous to human TBC1D4 (TBC1 domain family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Tbc1d4 Products (5)

mRNA	Protein	Name
NM_001081278.3	NP_001074747.2	TBC1 domain family member 4 isoform 3
NM_001404671.1	NP_001391600.1	TBC1 domain family member 4 isoform 1
NM_001404672.1	NP_001391601.1	TBC1 domain family member 4 isoform 2
NM_001404673.1	NP_001391602.1	TBC1 domain family member 4 isoform 4
NM_001404674.1	NP_001391603.1	TBC1 domain family member 4 isoform 5

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to insulin stimulus	IGI IGI: Inferred from genetic interaction	24349514	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TBC1 domain family member 4	akt substrate of 160 kDa

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14244	TBC1D4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbc1d4	NCBI	NCBI:9882