Best2 - bestrophin 2 Gene

Also Known as Vmd2l1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 212989

Summary

Contributes to Chloride Channel activity. Involved in chloride transmembrane transport and membrane depolarization. Acts upstream of or within chloride transport and sensory perception of smell. Located in cilium. Part of Chloride Channel complex. Is expressed in ovary; submandibular gland; testis; and thymus. Orthologous to human BEST2 (bestrophin 2). [provided by Alliance of Genome Resources, Apr 2022]

Best2 Products (1)

mRNA Protein Name
NM_001130194.1 NP_001123666.1 bestrophin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bicarbonate channel activity IDA
IDA: Inferred from direct assay
18400985 MGI
enables bicarbonate channel activity IMP
IMP: Inferred from mutant phenotype
20407206 MGI
contributes to chloride channel activity IDA
IDA: Inferred from direct assay
16912113 MGI
enables chloride channel activity IDA
IDA: Inferred from direct assay
16707793 MGI
Biological Process GO Annotation Evidence References Source
involved in bicarbonate transport IMP
IMP: Inferred from mutant phenotype
20407206 MGI
involved in chloride transmembrane transport IMP
IMP: Inferred from mutant phenotype
16912113 MGI
acts upstream of or within chloride transport IDA
IDA: Inferred from direct assay
16707793 MGI
involved in membrane depolarization IDA
IDA: Inferred from direct assay
16912113 MGI
involved in sensory perception of smell IEP
IEP: Inferred from expression pattern
16912113 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
20407206 MGI
part of chloride channel complex IDA
IDA: Inferred from direct assay
16912113 MGI
located in cilium IDA
IDA: Inferred from direct assay
16912113 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bestrophin-2

  • vitelliform macular dystrophy 2-like protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01475 BEST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Best2 NCBI NCBI:54831