Best2 - bestrophin 2 Gene

Mus musculus

Also known as Vmd2l1

Gene ID: 212989 | Gene type: protein coding

About Best2

Summary

Contributes to Chloride Channel activity. Involved in chloride transmembrane transport and membrane depolarization. Acts upstream of or within chloride transport and sensory perception of smell. Located in cilium. Part of Chloride Channel complex. Is expressed in ovary; submandibular gland; testis; and thymus. Orthologous to human BEST2 (bestrophin 2). [provided by Alliance of Genome Resources, Apr 2022]

Best2 Products(1)

mRNA	Protein	Name
NM_001130194.1	NP_001123666.1	bestrophin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables bicarbonate channel activity	IDA IDA: Inferred from direct assay	18400985	MGI
enables bicarbonate channel activity	IMP IMP: Inferred from mutant phenotype	20407206	MGI
contributes to chloride channel activity	IDA IDA: Inferred from direct assay	16912113	MGI
enables chloride channel activity	IDA IDA: Inferred from direct assay	16707793	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bicarbonate transport	IMP IMP: Inferred from mutant phenotype	20407206	MGI
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	16912113	MGI
acts upstream of or within chloride transport	IDA IDA: Inferred from direct assay	16707793	MGI
involved in membrane depolarization	IDA IDA: Inferred from direct assay	16912113	MGI
involved in sensory perception of smell	IEP IEP: Inferred from expression pattern	16912113	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	20407206	MGI
part of chloride channel complex	IDA IDA: Inferred from direct assay	16912113	MGI
located in cilium	IDA IDA: Inferred from direct assay	16912113	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bestrophin-2

vitelliform macular dystrophy 2-like protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01475	BEST2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Best2	NCBI	NCBI:54831

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