Tbr1 - T-box brain transcription factor 1 Gene

Mus musculus

Gene ID: 21375 | Gene type: protein coding

About Tbr1

Summary

Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including brain development; conditioned taste aversion; and specification of animal organ identity. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TBR1 (T-box brain transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbr1 Products(1)

mRNA	Protein	Name
NM_009322.3	NP_033348.2	T-box brain protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15584924	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14999075	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20615956	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	30186101	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within amygdala development	IMP IMP: Inferred from mutant phenotype	24441682	MGI
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	30186101	MGI
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	30186101	MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain	IGI IGI: Inferred from genetic interaction	23144223	MGI
acts upstream of or within conditioned taste aversion	IMP IMP: Inferred from mutant phenotype	24441682	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	30186101	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	16540585	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	20615956	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15584924	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15584924	MGI
acts upstream of or within regulation of axon guidance	IMP IMP: Inferred from mutant phenotype	11967891	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20615956	MGI
acts upstream of or within regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	20615956	MGI
acts upstream of or within specification of animal organ identity	IMP IMP: Inferred from mutant phenotype	20615956	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14999075	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-box brain protein 1

T-box brain gene 1	T-brain-1
TBR-1	TES-56

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14268	TBR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbr1	NCBI	NCBI:10716

Name
Email *

	Sorry, but the email address you supplied was invalid.