Tbr1 - T-box brain transcription factor 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21375

Summary

Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including brain development; conditioned taste aversion; and specification of animal organ identity. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TBR1 (T-box brain transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbr1 Products (1)

mRNA Protein Name
NM_009322.3 NP_033348.2 T-box brain protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15584924 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14999075 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20615956 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
30186101 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within amygdala development IMP
IMP: Inferred from mutant phenotype
24441682 MGI
involved in cerebral cortex development IMP
IMP: Inferred from mutant phenotype
30186101 MGI
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
30186101 MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain IGI
IGI: Inferred from genetic interaction
23144223 MGI
acts upstream of or within conditioned taste aversion IMP
IMP: Inferred from mutant phenotype
24441682 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
30186101 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
16540585 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
20615956 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15584924 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15584924 MGI
acts upstream of or within regulation of axon guidance IMP
IMP: Inferred from mutant phenotype
11967891 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20615956 MGI
acts upstream of or within regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
20615956 MGI
acts upstream of or within specification of animal organ identity IMP
IMP: Inferred from mutant phenotype
20615956 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14999075 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-box brain protein 1

  • T-box brain gene 1

  • T-brain-1

  • TBR-1

  • TES-56

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14268 TBR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbr1 NCBI NCBI:10716