Prepl - prolyl endopeptidase-like Gene

Also Known as mKIAA0436; 2810457N15Rik; 9530014L06Rik; D030028O16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 213760

Summary

Enables peptidase activity. Involved in Golgi to plasma membrane protein transport and retrograde transport, endosome to Golgi. Located in Golgi apparatus and Cytoskeleton. Colocalizes with trans-Golgi network. Is expressed in several structures, including diaphragm; nervous system; retina; tongue; and vertebral axis musculature. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like). [provided by Alliance of Genome Resources, Apr 2022]

Prepl Products (4)

mRNA Protein Name
NM_001163622.1 NP_001157094.1 prolyl endopeptidase-like isoform a
NM_001163623.1 NP_001157095.1 prolyl endopeptidase-like isoform b
NM_001163624.1 NP_001157096.1 prolyl endopeptidase-like isoform b
NM_145984.3 NP_666096.3 prolyl endopeptidase-like isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
21692504 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23321636 MGI
Biological Process GO Annotation Evidence References Source
involved in Golgi to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
23321636 MGI
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
23321636 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
23485813 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
23485813 MGI
colocalizes with trans-Golgi network IMP
IMP: Inferred from mutant phenotype
23321636 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl endopeptidase-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11084 PREPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prepl NCBI NCBI:9581