Tbx15 - T-box 15 Gene

Also Known as de; Tbx8; Tbx14; mmTBx8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21384

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic cranial skeleton morphogenesis. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; facial prominence; genitourinary system; and limb. Orthologous to human TBX15 (T-box transcription factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Tbx15 Products (3)

mRNA Protein Name
NM_001410561.1 NP_001397490.1 T-box transcription factor TBX15 isoform 2
NM_001410562.1 NP_001397491.1 T-box transcription factor TBX15 isoform 2
NM_009323.3 NP_033349.2 T-box transcription factor TBX15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17584735 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17584735 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17584735 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
17584735 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
15728667 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
15728667 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
15728667 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17584735 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription repressor complex IDA
IDA: Inferred from direct assay
17584735 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17584735 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-box transcription factor TBX15

  • T-box 14

  • T-box protein 14

  • T-box protein 15

  • T-box transcription factor TBX14

  • droopy ear

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14272 TBX15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbx15 NCBI NCBI:6913