Tcf7l1 - transcription factor 7 like 1 (T cell specific, HMG box) Gene

Also Known as Tcf3; Tcf-3; bHLHb21

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21415

Summary

Enables several functions, including DNA-binding transcription factor activity; beta-catenin binding activity; and chromatin binding activity. Acts upstream of or within several processes, including axial mesoderm morphogenesis; regulation of transcription, DNA-templated; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human TCF7L1 (transcription factor 7 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Tcf7l1 Products (2)

mRNA	Protein	Name
NM_001079822.2	NP_001073290.1	transcription factor 7-like 1 isoform 1
NM_009332.3	NP_033358.2	transcription factor 7-like 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16894029	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16894029	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	9488439	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18202148	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18202148	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior axis specification, embryo	IMP IMP: Inferred from mutant phenotype	14668413	MGI
acts upstream of or within axial mesoderm morphogenesis	IMP IMP: Inferred from mutant phenotype	14668413	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16894029	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15907834	MGI
acts upstream of or within regulation of somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18467660	MGI
acts upstream of or within regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18347094	MGI
acts upstream of or within skin development	IGI IGI: Inferred from genetic interaction	19718027	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	19718027	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	16894029	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15907834	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10498690	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor 7-like 1	HMG box transcription factor 3 T-cell factor 3 transcription factor 3 transcription factor 7-like 2 (T-cell specific, HMG box)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14309	TCF7L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcf7l1	NCBI	NCBI:83439