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Tfap2b - transcription factor AP-2 beta Gene

Also Known as Tcfap2b; AP2-beta; AP-2(beta); E130018K07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21419

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including artery morphogenesis; inorganic ion homeostasis; and limb morphogenesis. Acts upstream of with a negative effect on negative regulation of apoptotic process. Acts upstream of or within several processes, including animal organ development; fat cell differentiation; and sympathetic nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including genital tubercle; jaw; metanephros; nervous system; and sensory organ. Used to study Char syndrome; angle-closure glaucoma; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Orthologous to human TFAP2B (transcription factor AP-2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Tfap2b Products (3)

mRNA	Protein	Name
NM_001025305.3	NP_001020476.1	transcription factor AP-2-beta isoform 2
NM_001286340.2	NP_001273269.1	transcription factor AP-2-beta isoform 3
NM_009334.4	NP_033360.2	transcription factor AP-2-beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7555706	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21829553	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21829553	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11694877	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	21829553	MGI
involved in collecting duct development	IMP IMP: Inferred from mutant phenotype	12695560	MGI
involved in distal tubule development	IMP IMP: Inferred from mutant phenotype	12695560	MGI
involved in ductus arteriosus closure	IMP IMP: Inferred from mutant phenotype	18635823	MGI
involved in fat cell differentiation	IEP IEP: Inferred from expression pattern	15940393	MGI
involved in forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	21829553	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	18635823	MGI
involved in hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	21829553	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	9271117	MGI
involved in metanephric nephron development	IEP IEP: Inferred from expression pattern	7555706	MGI
acts upstream of negative effect negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17525748	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	21539825	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	21539825	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17525748	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7555706	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21829553	MGI
involved in regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	21829553	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21829553	MGI
involved in sensory organ development	IEP IEP: Inferred from expression pattern	7555706	MGI
involved in skin development	IEP IEP: Inferred from expression pattern	7555706	MGI
involved in smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	18635823	MGI
acts upstream of or within sympathetic nervous system development	IGI IGI: Inferred from genetic interaction	21539825	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7555706	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	25187989	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor AP-2-beta	activating enhancer-binding protein 2 beta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14409	TFAP2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tfap2b	NCBI	NCBI:7021