Nudt15 - nudix hydrolase 15 Gene

Also Known as MTH2; 6530403O17; A730068G11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214254

Summary

Enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity. Acts upstream of or within purine deoxyribonucleoside triphosphate catabolic process and response to Reactive Oxygen Species. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in thiopurine S-methyltransferase deficiency. Orthologous to human NUDT15 (nudix hydrolase 15). [provided by Alliance of Genome Resources, Apr 2022]

Nudt15 Products (2)

mRNA Protein Name
NM_001360484.1 NP_001347413.1 nucleotide triphosphate diphosphatase NUDT15
NM_172527.3 NP_766115.1 nucleotide triphosphate diphosphatase NUDT15

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IDA
IDA: Inferred from direct assay
12767940 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within purine deoxyribonucleoside triphosphate catabolic process IDA
IDA: Inferred from direct assay
12767940 MGI
acts upstream of or within response to reactive oxygen species IDA
IDA: Inferred from direct assay
12767940 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleotide triphosphate diphosphatase NUDT15

  • 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15

  • 8-oxo-dGTPase NUDT15

  • MutT homolog 2

  • nucleoside diphosphate-linked moiety X motif 15

  • nucleoside diphosphate-linked to another moiety X hydrolase 15

  • nudix (nucleoside diphosphate linked moiety X)-type moti

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139193 TH1760 Inhibitor / Unkown
HY-RS09665 NUDT15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nudt15 NCBI NCBI:55270