Myocd - myocardin Gene

Mus musculus

Also known as Srfcp; BSAC2A

Gene ID: 214384 | Gene type: protein coding

About Myocd

Summary

Enables several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including circulatory system development; negative regulation of vascular associated smooth muscle cell migration; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; circulatory system development; and regulation of transcription, DNA-templated. Located in chromatin and nucleus. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; paraxial mesenchyme; and respiratory system. Used to study bladder disease; dilated cardiomyopathy; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in congenital megabladder. Orthologous to human MYOCD (myocardin). [provided by Alliance of Genome Resources, Apr 2022]

Myocd Products(2)

mRNA	Protein	Name
NM_145136.5	NP_660118.3	myocardin isoform A
NM_146386.4	NP_666498.2	myocardin isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	16224064	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11439182	MGI
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	15601857	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	15601857	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11439182	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11439182	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19850880	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	14645532	MGI
involved in cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	11439182	MGI
acts upstream of or within cardiac ventricle development	IMP IMP: Inferred from mutant phenotype	21357509	MGI
acts upstream of or within cellular component maintenance	IMP IMP: Inferred from mutant phenotype	19850880	MGI
acts upstream of or within chromatin organization	IDA IDA: Inferred from direct assay	15601857	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	21357509	MGI
acts upstream of or within ductus arteriosus closure	IMP IMP: Inferred from mutant phenotype	18188448	MGI
involved in heart development	IDA IDA: Inferred from direct assay	24068960	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	11439182	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	21357509	MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19850880	MGI
acts upstream of negative regulation of cell adhesion molecule production	IDA IDA: Inferred from direct assay	28342807	MGI
acts upstream of or within negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	17940050	MGI
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IDA IDA: Inferred from direct assay	23825366	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15601857	MGI
involved in negative regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	23825366	MGI
involved in negative regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	23825366	MGI
acts upstream of or within positive regulation of DNA binding	IGI IGI: Inferred from genetic interaction	19342595	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15798203	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11439182	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23825366	MGI
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	24068960	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12640126	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19578358	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15601857	MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16224064	MGI
acts upstream of or within regulation of cell growth by extracellular stimulus	IDA IDA: Inferred from direct assay	11439182	MGI
acts upstream of or within regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	12640126	MGI
involved in regulation of phenotypic switching	IGI IGI: Inferred from genetic interaction	19578358	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14645532	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	12867591	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18511849	MGI
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	15601857	MGI
acts upstream of or within urinary bladder development	IMP IMP: Inferred from mutant phenotype	21357509	MGI
acts upstream of or within uterus development	IMP IMP: Inferred from mutant phenotype	21357509	MGI
involved in vascular associated smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	19578358	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	12867591	MGI
acts upstream of or within ventricular cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	21357509	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	24068960	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11439182	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myocardin

SRF co-factor protein (cardiac and smooth muscle)	SRF cofactor protein
basic SAP coiled-coil transcription activator 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08955	MYOCD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myocd	NCBI	NCBI:93649

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