Myocd - myocardin Gene

Also Known as Srfcp; BSAC2A

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 214384

Summary

Enables several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including circulatory system development; negative regulation of vascular associated smooth muscle cell migration; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; circulatory system development; and regulation of transcription, DNA-templated. Located in chromatin and nucleus. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; paraxial mesenchyme; and respiratory system. Used to study bladder disease; dilated cardiomyopathy; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in congenital megabladder. Orthologous to human MYOCD (myocardin). [provided by Alliance of Genome Resources, Apr 2022]

Myocd Products (2)

mRNA Protein Name
NM_145136.5 NP_660118.3 myocardin isoform A
NM_146386.4 NP_666498.2 myocardin isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables R-SMAD binding IPI
IPI: Inferred from physical interaction
16224064 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11439182 MGI
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
15601857 MGI
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
15601857 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11439182 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
11439182 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19850880 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
14645532 MGI
involved in cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
11439182 MGI
acts upstream of or within cardiac ventricle development IMP
IMP: Inferred from mutant phenotype
21357509 MGI
acts upstream of or within cellular component maintenance IMP
IMP: Inferred from mutant phenotype
19850880 MGI
acts upstream of or within chromatin organization IDA
IDA: Inferred from direct assay
15601857 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
21357509 MGI
acts upstream of or within ductus arteriosus closure IMP
IMP: Inferred from mutant phenotype
18188448 MGI
involved in heart development IDA
IDA: Inferred from direct assay
24068960 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
11439182 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
21357509 MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19850880 MGI
acts upstream of negative regulation of cell adhesion molecule production IDA
IDA: Inferred from direct assay
28342807 MGI
acts upstream of or within negative regulation of myotube differentiation IMP
IMP: Inferred from mutant phenotype
17940050 MGI
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IDA
IDA: Inferred from direct assay
23825366 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15601857 MGI
involved in negative regulation of vascular associated smooth muscle cell migration IDA
IDA: Inferred from direct assay
23825366 MGI
involved in negative regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
23825366 MGI
acts upstream of or within positive regulation of DNA binding IGI
IGI: Inferred from genetic interaction
19342595 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15798203 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11439182 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
23825366 MGI
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
24068960 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12640126 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19578358 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15601857 MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16224064 MGI
acts upstream of or within regulation of cell growth by extracellular stimulus IDA
IDA: Inferred from direct assay
11439182 MGI
acts upstream of or within regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
12640126 MGI
involved in regulation of phenotypic switching IGI
IGI: Inferred from genetic interaction
19578358 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14645532 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
12867591 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18511849 MGI
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
15601857 MGI
acts upstream of or within urinary bladder development IMP
IMP: Inferred from mutant phenotype
21357509 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
21357509 MGI
involved in vascular associated smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
19578358 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
12867591 MGI
acts upstream of or within ventricular cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
21357509 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in chromatin IDA
IDA: Inferred from direct assay
24068960 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11439182 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myocardin

  • SRF co-factor protein (cardiac and smooth muscle)

  • SRF cofactor protein

  • basic SAP coiled-coil transcription activator 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08955 MYOCD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Myocd NCBI NCBI:93649