Sema6d - sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D Gene

Also Known as mKIAA1479; D330011G23; 1110067B02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214968

Summary

Enables semaphorin receptor binding activity. Acts upstream of or within negative regulation of smooth muscle cell migration; positive regulation of smooth muscle cell migration; and ventricular system development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; gut mesenchyme; retina; and spinal ganglion or nerve. Orthologous to human SEMA6D (semaphorin 6D). [provided by Alliance of Genome Resources, Apr 2022]

Sema6d Products (8)

mRNA Protein Name
NM_001290997.2 NP_001277926.1 semaphorin-6D isoform Sema6D-2 precursor
NM_001291000.2 NP_001277929.1 semaphorin-6D isoform 3 precursor
NM_001407285.1 NP_001394214.1 semaphorin-6D isoform 7 precursor
NM_172537.5 NP_766125.2 semaphorin-6D isoform Sema6D-1 precursor
NM_199238.4 NP_954708.1 semaphorin-6D isoform Sema6D-2 precursor
NM_199239.4 NP_954709.1 semaphorin-6D isoform Sema6D-5 precursor
NM_199240.4 NP_954710.1 semaphorin-6D isoform Sema6D-6 precursor
NM_199241.4 NP_954711.1 semaphorin-6D isoform Sema6D-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14977921 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
16715077 MGI
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
17145500 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
IDA: Inferred from direct assay
16715077 MGI
acts upstream of or within negative regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
14977921 MGI
acts upstream of or within positive regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
14977921 MGI
involved in semaphorin-plexin signaling pathway IDA
IDA: Inferred from direct assay
16715077 MGI
acts upstream of smooth muscle cell migration IDA
IDA: Inferred from direct assay
14977921 MGI
acts upstream of or within ventricular system development IDA
IDA: Inferred from direct assay
14977921 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-6D

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12667 SEMA6D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema6d NCBI NCBI:80031