Sbno2 - strawberry notch 2 Gene

Also Known as Sno; Stno; F730040C21

Species: Mus musculus

Gene Type: protein coding

Gene ID: 216161

Summary

Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and macrophage activation involved in immune response. Acts upstream of or within several processes, including bone mineralization; bone trabecula morphogenesis; and osteoclast fusion. Predicted to be active in nucleus. Is expressed in submandibular gland primordium and vibrissa. Orthologous to human SBNO2 (strawberry Notch homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Sbno2 Products (4)

mRNA	Protein	Name
NM_001359635.1	NP_001346564.1	protein strawberry notch homolog 2 isoform 2
NM_001359636.1	NP_001346565.1	protein strawberry notch homolog 2 isoform 3
NM_001359637.1	NP_001346566.1	protein strawberry notch homolog 2 isoform 4
NM_183426.2	NP_906271.1	protein strawberry notch homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23980096	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	23980096	MGI
acts upstream of or within bone trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	23980096	MGI
involved in cellular response to interleukin-11	IDA IDA: Inferred from direct assay	25903009	MGI
involved in cellular response to interleukin-6	IDA IDA: Inferred from direct assay	25903009	MGI
involved in cellular response to leukemia inhibitory factor	IDA IDA: Inferred from direct assay	25903009	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	25903009	MGI
involved in macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	18025162	MGI
acts upstream of or within multinuclear osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	23980096	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18025162	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	23980096	MGI
acts upstream of or within osteoclast fusion	IMP IMP: Inferred from mutant phenotype	23980096	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23980096	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18025162	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein strawberry notch homolog 2	strawberry notch homolog 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12470	SBNO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sbno2	NCBI	NCBI:22904