Appl2 - adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 Gene

Mus musculus

Also known as Dip3b; Dip3 beta; DIP13 beta

Gene ID: 216190 | Gene type: protein coding

About Appl2

Summary

Predicted to enable phospholipid binding activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including adiponectin-activated signaling pathway; cellular response to hepatocyte growth factor stimulus; and regulation of vesicle-mediated transport. Located in early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; brain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2). [provided by Alliance of Genome Resources, Apr 2022]

Appl2 Products(1)

mRNA	Protein	Name
NM_145220.2	NP_660255.1	DCC-interacting protein 13-beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19661063	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adiponectin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	19661063	MGI
involved in cellular response to hepatocyte growth factor stimulus	IMP IMP: Inferred from mutant phenotype	26445298	MGI
involved in cold acclimation	IMP IMP: Inferred from mutant phenotype	29467283	MGI
involved in diet induced thermogenesis	IMP IMP: Inferred from mutant phenotype	29467283	MGI
involved in negative regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	19661063	MGI
involved in negative regulation of cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	19661063	MGI
involved in negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	25328665	MGI
involved in negative regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	19661063	MGI
involved in negative regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	28965332	MGI
involved in negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	28965332	MGI
involved in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	25568335	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	29467283	MGI
involved in positive regulation of macropinocytosis	IMP IMP: Inferred from mutant phenotype	27219021	MGI
involved in positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	25568335	MGI
involved in regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	26445298	MGI
involved in regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	27219021	MGI
involved in regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	27219021	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19661063	MGI
located in early phagosome	IDA IDA: Inferred from direct assay	25568335	MGI
located in early phagosome membrane	IDA IDA: Inferred from direct assay	27219021	MGI
located in macropinosome	IDA IDA: Inferred from direct assay	27219021	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	27219021	MGI
located in ruffle	IDA IDA: Inferred from direct assay	25568335	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	27219021	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DCC-interacting protein 13-beta

adapter protein containing PH domain, PTB domain and leucine zipper motif 2

dip13-beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00827	APLP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00868	APPL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Appl2	NCBI	NCBI:55198

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