Appl2 - adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 Gene

Also Known as Dip3b; Dip3 beta; DIP13 beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216190

Summary

Predicted to enable phospholipid binding activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including adiponectin-activated signaling pathway; cellular response to hepatocyte growth factor stimulus; and regulation of vesicle-mediated transport. Located in early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; brain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2). [provided by Alliance of Genome Resources, Apr 2022]

Appl2 Products (1)

mRNA Protein Name
NM_145220.2 NP_660255.1 DCC-interacting protein 13-beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19661063 MGI
Biological Process GO Annotation Evidence References Source
involved in adiponectin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
19661063 MGI
involved in cellular response to hepatocyte growth factor stimulus IMP
IMP: Inferred from mutant phenotype
26445298 MGI
involved in cold acclimation IMP
IMP: Inferred from mutant phenotype
29467283 MGI
involved in diet induced thermogenesis IMP
IMP: Inferred from mutant phenotype
29467283 MGI
involved in negative regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
19661063 MGI
involved in negative regulation of cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
19661063 MGI
involved in negative regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
25328665 MGI
involved in negative regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
19661063 MGI
involved in negative regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
28965332 MGI
involved in negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
28965332 MGI
involved in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
25568335 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
29467283 MGI
involved in positive regulation of macropinocytosis IMP
IMP: Inferred from mutant phenotype
27219021 MGI
involved in positive regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
25568335 MGI
involved in regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
26445298 MGI
involved in regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
27219021 MGI
involved in regulation of toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
27219021 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19661063 MGI
located in early phagosome IDA
IDA: Inferred from direct assay
25568335 MGI
located in early phagosome membrane IDA
IDA: Inferred from direct assay
27219021 MGI
located in macropinosome IDA
IDA: Inferred from direct assay
27219021 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
27219021 MGI
located in ruffle IDA
IDA: Inferred from direct assay
25568335 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
27219021 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DCC-interacting protein 13-beta

  • adapter protein containing PH domain, PTB domain and leucine zipper motif 2

  • dip13-beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00827 APLP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00868 APPL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Appl2 NCBI NCBI:55198