Slc17a8 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 Gene

Also Known as Vglut3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216227

Summary

Enables L-glutamate transmembrane transporter activity. Acts upstream of or within L-glutamate transmembrane transport. Located in synaptic vesicle membrane. Is integral component of synaptic vesicle membrane. Is expressed in brain; cochlear ganglion; and sensory organ. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a8 Products (2)

mRNA Protein Name
NM_001310710.1 NP_001297639.1 vesicular glutamate transporter 3 isoform 2
NM_182959.3 NP_892004.1 vesicular glutamate transporter 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glutamate uniporter activity IDA
IDA: Inferred from direct assay
12384506 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
12384506 MGI
involved in L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
18080752 MGI
involved in positive regulation of glutamate uptake involved in transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
18215623 MGI
involved in regulation of acetylcholine uptake IMP
IMP: Inferred from mutant phenotype
18278042 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
32306148 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
27458190 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23633129 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
12384506 MGI
is active in synaptic vesicle membrane IEP
IEP: Inferred from expression pattern
23633129 MGI
is active in synaptic vesicle membrane IMP
IMP: Inferred from mutant phenotype
23633129 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicular glutamate transporter 3

  • solute carrier family 17 member 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13041 SLC17A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc17a8 NCBI NCBI:246213