Slc17a8 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 Gene

Mus musculus

Also known as Vglut3

Gene ID: 216227 | Gene type: protein coding

About Slc17a8

Summary

Enables L-glutamate transmembrane transporter activity. Acts upstream of or within L-glutamate transmembrane transport. Located in synaptic vesicle membrane. Is integral component of synaptic vesicle membrane. Is expressed in brain; cochlear ganglion; and sensory organ. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a8 Products(2)

mRNA	Protein	Name
NM_001310710.1	NP_001297639.1	vesicular glutamate transporter 3 isoform 2
NM_182959.3	NP_892004.1	vesicular glutamate transporter 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate uniporter activity	IDA IDA: Inferred from direct assay	12384506	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	12384506	MGI
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	18080752	MGI
involved in positive regulation of glutamate uptake involved in transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	18215623	MGI
involved in regulation of acetylcholine uptake	IMP IMP: Inferred from mutant phenotype	18278042	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	32306148	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	27458190	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	23633129	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12384506	MGI
is active in synaptic vesicle membrane	IEP IEP: Inferred from expression pattern	23633129	MGI
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	23633129	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicular glutamate transporter 3

solute carrier family 17 member 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13041	SLC17A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc17a8	NCBI	NCBI:246213

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