Dynlt1b - dynein light chain Tctex-type 1B Gene

Also Known as AGS2; Dynlt1; Tctex1; Tctex-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21648

Summary

Enables G-protein beta-subunit binding activity and GTP-dependent protein binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of neurogenesis; and regulation of G protein-coupled receptor signaling pathway. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade and positive regulation of neuron projection development. Located in several cellular components, including cell body; growth cone; and photoreceptor inner segment. Is expressed in several structures, including brain; hemolymphoid system gland; liver; otocyst; and retina. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Apr 2022]

Dynlt1b Products (2)

mRNA Protein Name
NM_009342.2 NP_033368.1 dynein light chain Tctex-type 1
NM_009342.2 NP_033368.1 dynein light chain Tctex-type 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein beta-subunit binding IDA
IDA: Inferred from direct assay
17491591 MGI
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
21262767 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11148215 MGI
Biological Process GO Annotation Evidence References Source
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
9448628 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
22028875 MGI
involved in negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
19448628 MGI
acts upstream of or within positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17491591 MGI
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10559191 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
9677391 MGI
located in growth cone IDA
IDA: Inferred from direct assay
17491591 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
17491591 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
10399916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein light chain Tctex-type 1

  • T-complex testis-specific protein 1

  • activator of G-protein signaling 2

  • dynein light chain Tctex-type 1D

  • t-complex testis expressed 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04092 DYNLT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown