Wdpcp - WD repeat containing planar cell polarity effector Gene

Mus musculus

Also known as Frtz; homolog-13

Gene ID: 216560 | Gene type: protein coding

About Wdpcp

Summary

Acts upstream of or within several processes, including embryonic digit morphogenesis; glomerular visceral epithelial cell migration; and sensory organ development. Located in axonemal basal plate. Is expressed in alimentary system epithelium; brain; larynx; and nose. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 15 and congenital heart defects, hamartomas of tongue, and polysyndactyly. Orthologous to human WDPCP (WD repeat containing planar cell polarity effector). [provided by Alliance of Genome Resources, Apr 2022]

Wdpcp Products(2)

mRNA	Protein	Name
NM_001364768.1	NP_001351697.1	WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 2
NM_145425.3	NP_663400.2	WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	35427153	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24302887	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within auditory receptor cell morphogenesis	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within cilium organization	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within circulatory system development	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within digestive system development	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within embryonic organ development	IGI IGI: Inferred from genetic interaction	24302887	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within podocyte cell migration	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within regulation of establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within respiratory system development	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	24302887	MGI
acts upstream of or within tongue morphogenesis	IMP IMP: Inferred from mutant phenotype	27158779	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonemal basal plate	IDA IDA: Inferred from direct assay	24302887	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

WD repeat-containing and planar cell polarity effector protein fritz homolog

WD repeat-containing protein C2orf86 homolog

mFrtz

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15759	WDPCP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wdpcp	NCBI	NCBI:51057

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