Wdpcp - WD repeat containing planar cell polarity effector Gene

Also Known as Frtz; homolog-13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216560

Summary

Acts upstream of or within several processes, including embryonic digit morphogenesis; glomerular visceral epithelial cell migration; and sensory organ development. Located in axonemal basal plate. Is expressed in alimentary system epithelium; brain; larynx; and nose. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 15 and congenital heart defects, hamartomas of tongue, and polysyndactyly. Orthologous to human WDPCP (WD repeat containing planar cell polarity effector). [provided by Alliance of Genome Resources, Apr 2022]

Wdpcp Products (2)

mRNA Protein Name
NM_001364768.1 NP_001351697.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 2
NM_145425.3 NP_663400.2 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
35427153 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24302887 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within auditory receptor cell morphogenesis IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within cilium organization IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within circulatory system development IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within digestive system development IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within embryonic organ development IGI
IGI: Inferred from genetic interaction
24302887 MGI
acts upstream of or within establishment of protein localization IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within podocyte cell migration IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within regulation of establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within respiratory system development IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within tongue morphogenesis IMP
IMP: Inferred from mutant phenotype
27158779 MGI
Cellular Component GO Annotation Evidence References Source
located in axonemal basal plate IDA
IDA: Inferred from direct assay
24302887 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

WD repeat-containing and planar cell polarity effector protein fritz homolog

  • WD repeat-containing protein C2orf86 homolog

  • mFrtz

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15759 WDPCP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wdpcp NCBI NCBI:51057