Tdgf1 - teratocarcinoma-derived growth factor 1 Gene

Also Known as CR1; cripto

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21667

Summary

Enables several functions, including Wnt-protein binding activity; nodal binding activity; and type I activin receptor binding activity. Involved in several processes, including morphogenesis of a branching structure; nodal signaling pathway; and positive regulation of cell migration. Acts upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of fibroblast proliferation. Located in several cellular components, including Golgi apparatus; cell surface; and perinuclear region of cytoplasm. Is extrinsic component of plasma membrane. Is expressed in several structures, including blastocyst; brain; embryo mesoderm; extraembryonic component; and heart. Human ortholog(s) of this gene implicated in colon Cancer and congenital heart disease. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tdgf1 Products (2)

mRNA Protein Name
NM_011562.2 NP_035692.2 teratocarcinoma-derived growth factor precursor
NM_011562.2 NP_035692.2 teratocarcinoma-derived growth factor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
15797385 MGI
enables coreceptor activity IDA
IDA: Inferred from direct assay
11389842 MGI
enables nodal binding IPI
IPI: Inferred from physical interaction
12052855 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14966532 MGI
enables type I activin receptor binding IPI
IPI: Inferred from physical interaction
11389842 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axis specification IGI
IGI: Inferred from genetic interaction
18241853 MGI
acts upstream of or within anterior/posterior axis specification, embryo IMP
IMP: Inferred from mutant phenotype
9790191 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
9876177 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9876177 MGI
acts upstream of or within gastrulation IGI
IGI: Inferred from genetic interaction
18241853 MGI
involved in heart development IDA
IDA: Inferred from direct assay
9576836 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9876177 MGI
involved in morphogenesis of a branching structure IDA
IDA: Inferred from direct assay
11133982 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17991893 MGI
involved in nodal signaling pathway IGI
IGI: Inferred from genetic interaction
11389842 MGI
involved in nodal signaling pathway IMP
IMP: Inferred from mutant phenotype
12052855 MGI
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
11133982 MGI
acts upstream of or within positive regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
9876177 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
9876177 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17568773 MGI
acts upstream of or within regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
9876177 MGI
acts upstream of or within regulation of signal transduction IDA
IDA: Inferred from direct assay
17936261 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
9876177 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
8588926 MGI
located in cell surface IDA
IDA: Inferred from direct assay
17991893 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8588926 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
12052855 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
10640699 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8588926 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8588926 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10640699 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

teratocarcinoma-derived growth factor

  • TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)

  • cripto growth factor

  • epidermal growth factor-like Cripto protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14330 TDGF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16445 TDGF1P3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991640 Anti-TDGF1 antibody (huB3F6) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tdgf1 NCBI NCBI:6997