Adamts2 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 Gene

Also Known as pNPI; PCINP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216725

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]

Adamts2 Products (1)

mRNA Protein Name
NM_175643.3 NP_783574.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
16556917 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
16556917 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16556917 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
16556917 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
11284712 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11284712 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
16556917 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 2

  • a disintegrin and metalloproteinase with thrombospondin repeats

  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2

  • procollagen I/II amino propeptide-processing enzyme

  • procollagen N-endopeptidase

  • procollagen N-

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00301 ADAMTS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00304 ADAMTS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18103 Adamts4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19537 Adamts2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26033 Adamts2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts2 NCBI NCBI:9509