Dhrs7b - dehydrogenase/reductase (SDR family) member 7B Gene

Also Known as PexRAP

Species: Mus musculus

Gene Type: protein coding

Gene ID: 216820

Summary

Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in ether lipid biosynthetic process and neutrophil differentiation. Acts upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane; nucleus; and peroxisome. Part of transcription regulator complex. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). [provided by Alliance of Genome Resources, Apr 2022]

Dhrs7b Products (2)

mRNA	Protein	Name
NM_001172112.1	NP_001165583.1	dehydrogenase/reductase SDR family member 7B isoform 1
NM_145428.2	NP_663403.1	dehydrogenase/reductase SDR family member 7B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	28930673	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28930673	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	28930673	MGI
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	28930673	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	28930673	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	28930673	MGI
involved in ether lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	25565205	MGI
acts upstream of inflammatory response	IMP IMP: Inferred from mutant phenotype	25565205	MGI
acts upstream of or within negative regulation of protein binding	IDA IDA: Inferred from direct assay	28930673	MGI
involved in neutrophil differentiation	IMP IMP: Inferred from mutant phenotype	25565205	MGI
acts upstream of or within phosphatidylcholine biosynthetic process	IMP IMP: Inferred from mutant phenotype	28930673	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	28930673	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28930673	MGI
acts upstream of or within regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28930673	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28930673	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	28930673	MGI
located in nucleus	IDA IDA: Inferred from direct assay	28930673	MGI
located in peroxisome	IDA IDA: Inferred from direct assay	28930673	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	28930673	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dehydrogenase/reductase SDR family member 7B	short-chain dehydrogenase/reductase family 32C member 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03744	DHRS7B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dhrs7b	NCBI	NCBI:25979