2. Gene
  3. Rhbdf2 - rhomboid 5 homolog 2 Gene

Rhbdf2 - rhomboid 5 homolog 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as cub; Uncv; Rhbdl6; 4732465I17Rik

Gene ID: 217344 | Gene type: protein coding

About Rhbdf2

Summary

Involved in negative regulation of protein secretion. Located in endoplasmic reticulum membrane. Used to study nonepidermolytic palmoplantar keratoderma. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Rhbdf2 Products(4)

mRNA Protein Name
NM_001167680.2 NP_001161152.1 inactive rhomboid protein 2 isoform 1
NM_001403627.1 NP_001390556.1 inactive rhomboid protein 2 isoform 2
NM_001403628.1 NP_001390557.1 inactive rhomboid protein 2 isoform 3
NM_172572.4 NP_766160.2 inactive rhomboid protein 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22246777 MGI
NOT enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
21439629 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of protein secretion IDA
IDA: Inferred from direct assay
21439629 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
29897333 MGI
acts upstream of or within regulation of metalloendopeptidase activity IGI
IGI: Inferred from genetic interaction
29897333 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21439629 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29897333 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive rhomboid protein 2

iRhom2

rhomboid family member 2

rhomboid veinlet-like protein 6

rhomboid, veinlet-like 6

rhomboid-like protein 6

rhomboid-related protein

uncovered

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11935 RHBDF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rhbdf2 NCBI NCBI:79651