Rhbdf2 - rhomboid 5 homolog 2 Gene

Also Known as cub; Uncv; Rhbdl6; 4732465I17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 217344

Summary

Involved in negative regulation of protein secretion. Located in endoplasmic reticulum membrane. Used to study nonepidermolytic palmoplantar keratoderma. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Rhbdf2 Products (4)

mRNA Protein Name
NM_001167680.2 NP_001161152.1 inactive rhomboid protein 2 isoform 1
NM_001403627.1 NP_001390556.1 inactive rhomboid protein 2 isoform 2
NM_001403628.1 NP_001390557.1 inactive rhomboid protein 2 isoform 3
NM_172572.4 NP_766160.2 inactive rhomboid protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22246777 MGI
NOT enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
21439629 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein secretion IDA
IDA: Inferred from direct assay
21439629 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
29897333 MGI
acts upstream of or within regulation of metalloendopeptidase activity IGI
IGI: Inferred from genetic interaction
29897333 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21439629 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29897333 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive rhomboid protein 2

  • iRhom2

  • rhomboid family member 2

  • rhomboid veinlet-like protein 6

  • rhomboid, veinlet-like 6

  • rhomboid-like protein 6

  • rhomboid-related protein

  • uncovered

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11935 RHBDF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rhbdf2 NCBI NCBI:79651