Tmc8 - transmembrane channel-like gene family 8 Gene

Also Known as EVIN2; Ever2; mFLJ00400

Species: Mus musculus

Gene Type: protein coding
Gene ID: 217356

Summary

Predicted to enable mechanosensitive ion channel activity; protein sequestering activity; and tumor necrosis factor binding activity. Predicted to be involved in several processes, including negative regulation of protein binding activity; regulation of extrinsic apoptotic signaling pathway via death domain receptors; and zinc ion homeostasis. Predicted to act upstream of or within ion transport. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC8 (transmembrane channel like 8). [provided by Alliance of Genome Resources, Apr 2022]

Tmc8 Products (4)

mRNA Protein Name
NM_001195088.1 NP_001182017.1 transmembrane channel-like protein 8 isoform A
NM_001195089.1 NP_001182018.1 transmembrane channel-like protein 8 isoform B
NM_001195090.1 NP_001182019.1 transmembrane channel-like protein 8 isoform D
NM_181856.2 NP_862904.1 transmembrane channel-like protein 8 isoform C

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32917726 MGI
Biological Process GO Annotation Evidence References Source
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
32917726 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane channel-like protein 8

  • epidermodysplasia verruciformis 2

  • epidermodysplasia verruciformis protein 2 homolog

  • transmembrane channel-like 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14628 TMC8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmc8 NCBI NCBI:147138