Terf2 - telomeric repeat binding factor 2 Gene

Also Known as TRF2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21750

Summary

Enables double-stranded telomeric DNA binding activity and protein homodimerization activity. Involved in anterograde axonal transport; negative regulation of telomere maintenance via recombination; and telomeric loop formation. Acts upstream of or within in utero embryonic development; positive regulation of telomere maintenance; and protection from non-homologous end joining at telomere. Located in chromosome, telomeric region and male germ cell nucleus. Is expressed in cerebral cortex and cortical plate. Used to study xeroderma pigmentosum. Orthologous to human TERF2 (telomeric repeat binding factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Terf2 Products (16)

mRNA Protein Name
NM_001083118.2 NP_001076587.1 telomeric repeat-binding factor 2 isoform 2
NM_001286200.1 NP_001273129.1 telomeric repeat-binding factor 2 isoform 3
NM_001371065.1 NP_001357994.1 telomeric repeat-binding factor 2 isoform 5
NM_001371066.1 NP_001357995.1 telomeric repeat-binding factor 2 isoform 6
NM_001371067.1 NP_001357996.1 telomeric repeat-binding factor 2 isoform 7
NM_001413758.1 NP_001400687.1 telomeric repeat-binding factor 2 isoform 8
NM_001413759.1 NP_001400688.1 telomeric repeat-binding factor 2 isoform 9
NM_009353.2 NP_033379.2 telomeric repeat-binding factor 2 isoform 1
NM_001083118.2 NP_001076587.1 telomeric repeat-binding factor 2 isoform 2
NM_001286200.1 NP_001273129.1 telomeric repeat-binding factor 2 isoform 3
NM_001371065.1 NP_001357994.1 telomeric repeat-binding factor 2 isoform 5
NM_001371066.1 NP_001357995.1 telomeric repeat-binding factor 2 isoform 6
NM_001371067.1 NP_001357996.1 telomeric repeat-binding factor 2 isoform 7
NM_001413758.1 NP_001400687.1 telomeric repeat-binding factor 2 isoform 8
NM_001413759.1 NP_001400688.1 telomeric repeat-binding factor 2 isoform 9
NM_009353.2 NP_033379.2 telomeric repeat-binding factor 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded telomeric DNA binding IMP
IMP: Inferred from mutant phenotype
9326950 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20339076 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
9326950 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
14690602 MGI
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
23685356 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15968270 MGI
involved in negative regulation of telomere maintenance via recombination IMP
IMP: Inferred from mutant phenotype
24120135 MGI
acts upstream of or within positive regulation of telomere maintenance IDA
IDA: Inferred from direct assay
15968270 MGI
acts upstream of or within positive regulation of telomere maintenance IMP
IMP: Inferred from mutant phenotype
15968270 MGI
acts upstream of or within protection from non-homologous end joining at telomere IDA
IDA: Inferred from direct assay
15968270 MGI
acts upstream of or within protection from non-homologous end joining at telomere IMP
IMP: Inferred from mutant phenotype
15968270 MGI
involved in protection from non-homologous end joining at telomere IMP
IMP: Inferred from mutant phenotype
20619712 MGI
acts upstream of telomere maintenance IDA
IDA: Inferred from direct assay
15968270 MGI
acts upstream of telomere maintenance IMP
IMP: Inferred from mutant phenotype
15968270 MGI
acts upstream of or within telomere maintenance IMP
IMP: Inferred from mutant phenotype
15010310 MGI
involved in telomeric loop formation IMP
IMP: Inferred from mutant phenotype
24120135 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
15109494 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
17696610 MGI
part of telomere cap complex IDA
IDA: Inferred from direct assay
28031483 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

telomeric repeat-binding factor 2

  • TTAGGG repeat-binding factor 2

  • telomeric DNA-binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14373 TERF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14374 TERF2IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Terf2 NCBI NCBI:7014