Mylip - myosin regulatory light chain interacting protein Gene

Also Known as Mir; 9430057C20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 218203

Summary

Enables ubiquitin protein Ligase activity. Involved in several processes, including Cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MYLIP (Myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Mylip Products (1)

mRNA Protein Name
NM_153789.3 NP_722484.2 E3 ubiquitin-protein ligase MYLIP

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
19520913 MGI
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
19520913 MGI
Biological Process GO Annotation Evidence References Source
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
19520913 MGI
involved in negative regulation of low-density lipoprotein particle clearance IDA
IDA: Inferred from direct assay
19520913 MGI
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
19520913 MGI
involved in protein destabilization IDA
IDA: Inferred from direct assay
19520913 MGI
involved in regulation of low-density lipoprotein particle receptor catabolic process IMP
IMP: Inferred from mutant phenotype
19520913 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19520913 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MYLIP

  • RING-type E3 ubiquitin transferase MYLIP

  • idol

  • inducible degrader of the LDL-receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08922 MYLIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mylip NCBI NCBI:29116