Mylip - myosin regulatory light chain interacting protein Gene

Mus musculus

Also known as Mir; 9430057C20Rik

Gene ID: 218203 | Gene type: protein coding

About Mylip

Summary

Enables ubiquitin protein Ligase activity. Involved in several processes, including Cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MYLIP (Myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Mylip Products(1)

mRNA	Protein	Name
NM_153789.3	NP_722484.2	E3 ubiquitin-protein ligase MYLIP

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	19520913	MGI
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	19520913	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	19520913	MGI
involved in negative regulation of low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	19520913	MGI
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19520913	MGI
involved in protein destabilization	IDA IDA: Inferred from direct assay	19520913	MGI
involved in regulation of low-density lipoprotein particle receptor catabolic process	IMP IMP: Inferred from mutant phenotype	19520913	MGI
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19520913	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MYLIP

RING-type E3 ubiquitin transferase MYLIP	idol
inducible degrader of the LDL-receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08922	MYLIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mylip	NCBI	NCBI:29116

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