Marveld2 - MARVEL (membrane-associating) domain containing 2 Gene

Mus musculus

Also known as Tric; Trica; Tricb; Tricc; MARVD2; Mrvldc2

Gene ID: 218518 | Gene type: protein coding

About Marveld2

Summary

Acts upstream of or within cell-cell junction organization and sensory perception of sound. Located in Schmidt-Lanterman incisure; paranodal junction; and tight junction. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 49. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 49. Orthologous to human MARVELD2 (MARVEL domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Marveld2 Products(2)

mRNA	Protein	Name
NM_001038602.4	NP_001033691.1	MARVEL domain-containing protein 2 isoform 1
NM_178410.3	NP_848497.2	MARVEL domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23239027	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	16365161	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	23979167	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	21097846	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	16365161	MGI
located in paranodal junction	IDA IDA: Inferred from direct assay	21097846	MGI
located in tight junction	IDA IDA: Inferred from direct assay	23239027	MGI
located in tricellular tight junction	IDA IDA: Inferred from direct assay	16365161	MGI
located in tricellular tight junction	IMP IMP: Inferred from mutant phenotype	25217574	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MARVEL domain-containing protein 2

tricellulin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08155	MARVELD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Marveld2	NCBI	NCBI:153562

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