Nkx2-1 - NK2 homeobox 1 Gene

Also Known as T/EBP; Titf1; Ttf-1; Nkx2.1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21869

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of circadian rhythm; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-1 Products (4)

mRNA Protein Name
NM_001403580.1 NP_001390509.1 homeobox protein Nkx-2.1 isoform 2
NM_009385.4 NP_033411.3 homeobox protein Nkx-2.1 isoform 1
NM_001403580.1 NP_001390509.1 homeobox protein Nkx-2.1 isoform 2
NM_009385.4 NP_033411.3 homeobox protein Nkx-2.1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11733512 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
7896788 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22356123 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21402781 MGI
enables intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22955271 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11733512 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7896788 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18632661 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within GABAergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
11163262 MGI
acts upstream of or within Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
12399445 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
17522155 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
8557195 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
11830575 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
12930780 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
8557195 MGI
acts upstream of or within cerebral cortex GABAergic interneuron differentiation IMP
IMP: Inferred from mutant phenotype
15028753 MGI
acts upstream of or within cerebral cortex cell migration IMP
IMP: Inferred from mutant phenotype
18786357 MGI
acts upstream of or within cerebral cortex neuron differentiation IGI
IGI: Inferred from genetic interaction
18339674 MGI
acts upstream of or within cerebral cortex neuron differentiation IMP
IMP: Inferred from mutant phenotype
18339674 MGI
acts upstream of or within club cell differentiation IGI
IGI: Inferred from genetic interaction
17164424 MGI
acts upstream of or within developmental induction IMP
IMP: Inferred from mutant phenotype
9806931 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
8557195 MGI
acts upstream of or within forebrain dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
10393115 MGI
acts upstream of or within forebrain neuron differentiation IMP
IMP: Inferred from mutant phenotype
11163262 MGI
acts upstream of or within forebrain neuron fate commitment IGI
IGI: Inferred from genetic interaction
18339674 MGI
acts upstream of or within forebrain neuron fate commitment IMP
IMP: Inferred from mutant phenotype
18339674 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
32868762 MGI
acts upstream of or within globus pallidus development IMP
IMP: Inferred from mutant phenotype
20181579 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
11163262 MGI
involved in hypothalamus development IMP
IMP: Inferred from mutant phenotype
32868762 MGI
acts upstream of or within interneuron migration IMP
IMP: Inferred from mutant phenotype
18786357 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
11854318 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
21350014 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10706142 MGI
acts upstream of or within lung saccule development IGI
IGI: Inferred from genetic interaction
17164424 MGI
acts upstream of or within menarche IMP
IMP: Inferred from mutant phenotype
17182767 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22356123 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18786357 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
18786356 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
12902388 MGI
acts upstream of or within oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
11171336 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
12930780 MGI
acts upstream of or within phospholipid metabolic process IGI
IGI: Inferred from genetic interaction
17164424 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
9806931 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15356023 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
14970209 MGI
involved in positive regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
22356123 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7896788 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16510470 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11733512 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18632661 MGI
acts upstream of or within telencephalon cell migration IMP
IMP: Inferred from mutant phenotype
18786357 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
18786356 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
16150900 MGI
acts upstream of or within thyroid gland development IMP
IMP: Inferred from mutant phenotype
15581879 MGI
acts upstream of or within type II pneumocyte differentiation IGI
IGI: Inferred from genetic interaction
17164424 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
7896788 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
11733512 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-2.1

  • thyroid nuclear factor 1

  • thyroid transcription factor 1

  • thyroid-specific enhancer-binding protein

  • tinman

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W331198 Tralopyril Inducer 99.70% Unkown
HY-RS09327 NKX2-1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx2-1 NCBI NCBI:7080