Nkx2-1 - NK2 homeobox 1 Gene

Mus musculus

Also known as T/EBP; Titf1; Ttf-1; Nkx2.1

Gene ID: 21869 | Gene type: protein coding

About Nkx2-1

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of circadian rhythm; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-1 Products(4)

mRNA	Protein	Name
NM_001403580.1	NP_001390509.1	homeobox protein Nkx-2.1 isoform 2
NM_009385.4	NP_033411.3	homeobox protein Nkx-2.1 isoform 1
NM_001403580.1	NP_001390509.1	homeobox protein Nkx-2.1 isoform 2
NM_009385.4	NP_033411.3	homeobox protein Nkx-2.1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11733512	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7896788	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22356123	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21402781	MGI
enables intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22955271	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11733512	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7896788	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18632661	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within GABAergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	11163262	MGI
acts upstream of or within Leydig cell differentiation	IMP IMP: Inferred from mutant phenotype	12399445	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	17522155	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	8557195	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	11830575	MGI
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	12930780	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	8557195	MGI
acts upstream of or within cerebral cortex GABAergic interneuron differentiation	IMP IMP: Inferred from mutant phenotype	15028753	MGI
acts upstream of or within cerebral cortex cell migration	IMP IMP: Inferred from mutant phenotype	18786357	MGI
acts upstream of or within cerebral cortex neuron differentiation	IGI IGI: Inferred from genetic interaction	18339674	MGI
acts upstream of or within cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	18339674	MGI
acts upstream of or within club cell differentiation	IGI IGI: Inferred from genetic interaction	17164424	MGI
acts upstream of or within developmental induction	IMP IMP: Inferred from mutant phenotype	9806931	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	8557195	MGI
acts upstream of or within forebrain dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	10393115	MGI
acts upstream of or within forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	11163262	MGI
acts upstream of or within forebrain neuron fate commitment	IGI IGI: Inferred from genetic interaction	18339674	MGI
acts upstream of or within forebrain neuron fate commitment	IMP IMP: Inferred from mutant phenotype	18339674	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	32868762	MGI
acts upstream of or within globus pallidus development	IMP IMP: Inferred from mutant phenotype	20181579	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	11163262	MGI
involved in hypothalamus development	IMP IMP: Inferred from mutant phenotype	32868762	MGI
acts upstream of or within interneuron migration	IMP IMP: Inferred from mutant phenotype	18786357	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	11854318	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	21350014	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	10706142	MGI
acts upstream of or within lung saccule development	IGI IGI: Inferred from genetic interaction	17164424	MGI
acts upstream of or within menarche	IMP IMP: Inferred from mutant phenotype	17182767	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22356123	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18786357	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	18786356	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	12902388	MGI
acts upstream of or within oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	11171336	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	12930780	MGI
acts upstream of or within phospholipid metabolic process	IGI IGI: Inferred from genetic interaction	17164424	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	9806931	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15356023	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	14970209	MGI
involved in positive regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	22356123	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7896788	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16510470	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11733512	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18632661	MGI
acts upstream of or within telencephalon cell migration	IMP IMP: Inferred from mutant phenotype	18786357	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	18786356	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	16150900	MGI
acts upstream of or within thyroid gland development	IMP IMP: Inferred from mutant phenotype	15581879	MGI
acts upstream of or within type II pneumocyte differentiation	IGI IGI: Inferred from genetic interaction	17164424	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	7896788	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	11733512	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-2.1

thyroid nuclear factor 1	thyroid transcription factor 1
thyroid-specific enhancer-binding protein	tinman

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W331198	Tralopyril	Inducer	99.70%	Unkown
HY-RS09327	NKX2-1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx2-1	NCBI	NCBI:7080

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