Tkt - transketolase Gene

Also Known as p68

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21881

Summary

This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013]

Tkt Products (1)

mRNA Protein Name
NM_009388.6 NP_033414.1 transketolase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transketolase activity IDA
IDA: Inferred from direct assay
5360673 MGI
Biological Process GO Annotation Evidence References Source
involved in pentose-phosphate shunt IDA
IDA: Inferred from direct assay
5360673 MGI
involved in pentose-phosphate shunt, non-oxidative branch IMP
IMP: Inferred from mutant phenotype
32295803 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
12167708 MGI
involved in xylulose 5-phosphate biosynthetic process IDA
IDA: Inferred from direct assay
5360673 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
5360673 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transketolase

  • TK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03623 DDR2 Human Pre-designed siRNA Set A / Unkown
HY-RS14559 TKT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17323 Tkt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23778 Tkt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tkt NCBI NCBI:7086