Fermt2 - fermitin family member 2 Gene

Mus musculus

Also known as Mig2; Plekhc1; Kindlin-2

Gene ID: 218952 | Gene type: protein coding

About Fermt2

Summary

Enables actin filament binding activity. Involved in several processes, including focal adhesion assembly; Integrin activation; and positive regulation of osteoblast differentiation. Located in stress fiber. Is expressed in several structures, including brain ventricular layer; genitourinary system; gut; immune system; and musculature. Orthologous to human FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Apr 2022]

Fermt2 Products(3)

mRNA	Protein	Name
NM_001360525.1	NP_001347454.1	fermitin family homolog 2 isoform 1
NM_001360526.1	NP_001347455.1	fermitin family homolog 2 isoform 2
NM_146054.3	NP_666166.2	fermitin family homolog 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	16876785	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adherens junction maintenance	IMP IMP: Inferred from mutant phenotype	28799653	MGI
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	18483218	MGI
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18483218	MGI
involved in integrin activation	IMP IMP: Inferred from mutant phenotype	18483218	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	29496737	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	29496737	MGI
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	28799653	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	29496737	MGI
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	18483218	MGI
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	18483218	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in stress fiber	IDA IDA: Inferred from direct assay	16876785	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fermitin family homolog 2

mitogen inducible 2	pleckstrin homology domain containing, family C (with FERM domain) member 1
pleckstrin homology domain-containing family C member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04865	FERMT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fermt2	NCBI	NCBI:10979

Name
Email *

	Sorry, but the email address you supplied was invalid.