Fermt2 - fermitin family member 2 Gene

Also Known as Mig2; Plekhc1; Kindlin-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 218952

Summary

Enables actin filament binding activity. Involved in several processes, including focal adhesion assembly; Integrin activation; and positive regulation of osteoblast differentiation. Located in stress fiber. Is expressed in several structures, including brain ventricular layer; genitourinary system; gut; immune system; and musculature. Orthologous to human FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Apr 2022]

Fermt2 Products (3)

mRNA Protein Name
NM_001360525.1 NP_001347454.1 fermitin family homolog 2 isoform 1
NM_001360526.1 NP_001347455.1 fermitin family homolog 2 isoform 2
NM_146054.3 NP_666166.2 fermitin family homolog 2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
16876785 MGI
Biological Process GO Annotation Evidence References Source
involved in adherens junction maintenance IMP
IMP: Inferred from mutant phenotype
28799653 MGI
involved in cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
18483218 MGI
involved in focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
18483218 MGI
involved in integrin activation IMP
IMP: Inferred from mutant phenotype
18483218 MGI
involved in limb development IMP
IMP: Inferred from mutant phenotype
29496737 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
29496737 MGI
involved in negative regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
28799653 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
29496737 MGI
involved in protein localization to membrane IMP
IMP: Inferred from mutant phenotype
18483218 MGI
involved in substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
18483218 MGI
Cellular Component GO Annotation Evidence References Source
located in stress fiber IDA
IDA: Inferred from direct assay
16876785 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fermitin family homolog 2

  • mitogen inducible 2

  • pleckstrin homology domain containing, family C (with FERM domain) member 1

  • pleckstrin homology domain-containing family C member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04865 FERMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fermt2 NCBI NCBI:10979