2. Gene
  3. Otop1 - otopetrin 1 Gene

Otop1 - otopetrin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as tlt; Otp1; A530025J20Rik

Gene ID: 21906 | Gene type: protein coding

About Otop1

Summary

Enables proton channel activity. Involved in cellular response to Insulin stimulus; negative regulation of interferon-gamma-mediated signaling pathway; and proton transmembrane transport. Acts upstream of or within detection of gravity and inner ear morphogenesis. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including adrenal gland; inner ear; integumental system; stomach; and thymus. Orthologous to human OTOP1 (otopetrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Otop1 Products(1)

mRNA Protein Name
NM_172709.3 NP_766297.2 proton channel OTOP1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables proton channel activity IDA
IDA: Inferred from direct assay
29371428 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
24379350 MGI
acts upstream of or within detection of gravity IMP
IMP: Inferred from mutant phenotype
12651873 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
12651873 MGI
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24379350 MGI
involved in proton transmembrane transport IDA
IDA: Inferred from direct assay
29371428 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
12651873 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29371428 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proton channel OTOP1

tilted

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-179491 OTOP1-IN-1 Inhibitor / Unkown
HY-RS09864 OTOP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Otop1 NCBI NCBI:133060