Tlx1 - T cell leukemia, homeobox 1 Gene

Also Known as Hox11; Tlx-1; Hox-11

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21908

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and spleen development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; ear; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in adult T-cell leukemia. Orthologous to human TLX1 (T cell leukemia homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Tlx1 Products (1)

mRNA	Protein	Name
NM_021901.3	NP_068701.1	T-cell leukemia homeobox protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15944191	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within animal organ formation	IMP IMP: Inferred from mutant phenotype	11356032	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	11356032	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15944191	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	12023301	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	12023301	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15944191	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15944191	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	15944191	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	11356032	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15944191	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-cell leukemia homeobox protein 1	homeobox TLX-1 homeobox protein Hox-11

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14602	TLX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlx1	NCBI	NCBI:3195