2. Gene
  3. Tlx2 - T cell leukemia, homeobox 2 Gene

Tlx2 - T cell leukemia, homeobox 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Enx; NCX; Ncx1; Tlx1l1; Tlx1l2; Hox11l1; Hox11L.1

Gene ID: 21909 | Gene type: protein coding

About Tlx2

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within enteric nervous system development; mesoderm formation; and negative regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; primitive streak; and urethra. Used to study intestinal pseudo-obstruction. Orthologous to human TLX2 (T cell leukemia homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Tlx2 Products(1)

mRNA Protein Name
NM_009392.2 NP_033418.1 T-cell leukemia homeobox protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9738002 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within enteric nervous system development IMP
IMP: Inferred from mutant phenotype
9259577 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
9550720 MGI
acts upstream of or within negative regulation of dendrite morphogenesis IDA
IDA: Inferred from direct assay
9738002 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9738002 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9738002 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell leukemia homeobox protein 2

PMUR10F

enteric neuron homeobox protein

homeo box 11-like 1

homeobox TLX-2

homeobox protein Hox-11L1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14603 TLX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlx2 NCBI NCBI:3196