2. Gene
  3. Cenpj - centromere protein J Gene

Cenpj - centromere protein J Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as LAP; CPAP; Gm81; LIP1; Sas4; 4932437H03Rik

Gene ID: 219103 | Gene type: protein coding

About Cenpj

Summary

Predicted to enable several functions, including gamma-tubulin binding activity; identical protein binding activity; and transcription coactivator activity. Acts upstream of or within organelle assembly; positive regulation of non-motile cilium assembly; and smoothened signaling pathway. Located in centriole and ciliary basal body. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and vibrissa. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 4; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 6. Orthologous to human CENPJ (centromere protein J). [provided by Alliance of Genome Resources, Apr 2022]

Cenpj Products(3)

mRNA Protein Name
NM_001014996.3 NP_001014996.2 centromere protein J isoform 1
NM_001403533.1 NP_001390462.1 centromere protein J isoform 2
NM_001403534.1 NP_001390463.1 centromere protein J isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12198240 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within centriole assembly IMP
IMP: Inferred from mutant phenotype
24706806 MGI
acts upstream of or within centriole replication IMP
IMP: Inferred from mutant phenotype
24706806 MGI
acts upstream of or within centrosome duplication IMP
IMP: Inferred from mutant phenotype
23213448 MGI
acts upstream of or within motile cilium assembly IMP
IMP: Inferred from mutant phenotype
24706806 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
23213448 MGI
acts upstream of or within positive regulation of non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
23213448 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
24706806 MGI
Cellular Component GO Annotation Evidence Reference Source
located in centriole IDA
IDA: Inferred from direct assay
23213448 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
23213448 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centromere protein J

CENP-J

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02482 CENPJ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cenpj NCBI NCBI:55835