Tpmt - thiopurine methyltransferase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22017

Summary

Enables thiopurine S-methyltransferase activity. Predicted to be involved in xenobiotic metabolic process. Predicted to act upstream of or within methylation. Predicted to be located in cytoplasm. Is expressed in metanephros. Used to study thiopurine S-methyltransferase deficiency. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Tpmt Products (1)

mRNA Protein Name
NM_016785.2 NP_058065.2 thiopurine S-methyltransferase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables thiopurine S-methyltransferase activity IDA
IDA: Inferred from direct assay
9539138 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thiopurine S-methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14940 TPMT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134062 7-Methyl-6-mercaptopurine / Unkown
HY-RS18794 Tpmt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25283 Tpmt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpmt NCBI NCBI:7172