RASGEF1A - RasGEF domain family member 1A Gene

Homo sapiens

Also known as CG4853

Gene ID: 221002 | Gene type: protein coding

About RASGEF1A

Cytogenetic location: 10q11.21 Genomic coordinates (GRCh38): 10:43,194,535-43,267,065 (from NCBI)

This gene has 5 transcripts (splice variants), 125 orthologues and 24 paralogues. Broad expression in brain (RPKM 7.0), bone marrow (RPKM 2.1) and 17 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in cell migration and positive regulation of Ras protein signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RASGEF1A Products(2)

mRNA	Protein	Name
NM_001282862.2	NP_001269791.1	ras-GEF domain-containing family member 1A isoform 1
NM_145313.4	NP_660356.2	ras-GEF domain-containing family member 1A isoform 2

RASGEF1A Protein Structure

RasGEF_N

RasGEF

0
100
200
300
400
481 a.a.

Protein Preferred Names

Protein Names

ras-GEF domain-containing family member 1A

CG4853 gene product

Related Diseases

Diseases

Alias

Intrahepatic Cholangiocarcinoma

Cholangiocarcinoma	Intrahepatic Bile Duct Carcinoma
Peripheral Cholangiocarcinoma	Peripheral Intrahepatic Cholangiocarcinoma
Adenocarcinoma Of Intra-Hepatic Bile Ducts	Cholangiocarcinoma, Unspecified Site
Cholangiocarcinoma Of Liver

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To	Extrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma	Chlc
Chlc, Susceptibility To	Cc
Cholangiocarcinoma Of Biliary Tract	Cholangiocellular Carcinoma
Distal Cholangiocarcinoma	Perihilar Cholangiocarcinoma
Bile Duct Cancer	Cca
Adult Primary Cholangiocellular Carcinoma	Bile Duct Carcinoma

Deafness, Autosomal Recessive 97

DFNB97	Autosomal Recessive Nonsyndromic Deafness 97
Autosomal Recessive Deafness 97	Deafness, Autosomal Recessive, 97
Deafness, Autosomal Recessive, Type 97

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

Catecholaminergic Polymorphic Ventricular Tachycardia 1	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
CPVT1	Ventricular Tachycardia, Stress-Induced Polymorphic
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Cvpt1
Double Tachycardia Induced By Catecholamines	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Paroxysmal Ventricular Fibrillation
Syncopal Paroxysmal Tachycardia	Syncopal Tachyarythmia
Ventricular Tachycardia Catecholaminergic Polymorphic 1	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1
Multifocal Pvcs	Multifocal Premature Ventricular Beats
Paroxysmal Familial Ventricular Fibrillation	Catecholaminergic Polymorphic Ventricular Tachycardia Type 1

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11688	RASGEF1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RASGEF1A	MGD	MGI:1917977
Macaca mulatta	RASGEF1A	VGNC	VGNC:76525
Rattus norvegicus	RASGEF1A	RGD	RGD:1305836
Canis familiaris	RASGEF1A	VGNC	VGNC:45367
Felis catus	RASGEF1A	VGNC	VGNC:97600
Bos taurus	RASGEF1A	VGNC	VGNC:33743

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