2. Gene
  3. SLC39A12 - solute carrier family 39 member 12 Gene

SLC39A12 - solute carrier family 39 member 12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZIP12; ZIP-12; LZT-Hs8; bA570F3.1

Gene ID: 221074 | Gene type: protein coding

About SLC39A12

Cytogenetic location: 10p12.33 Genomic coordinates (GRCh38): 10:17,951,918-18,043,285 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues and 6 paralogues. Restricted expression toward brain (RPKM 9.2).

Summary

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]

SLC39A12 Products(4)

mRNA Protein Name
NM_001145195.2 NP_001138667.1 zinc transporter ZIP12 isoform 1 precursor
NM_001282733.2 NP_001269662.1 zinc transporter ZIP12 isoform 3 precursor
NM_001282734.2 NP_001269663.1 zinc transporter ZIP12 isoform 4
NM_152725.4 NP_689938.2 zinc transporter ZIP12 isoform 2 precursor

SLC39A12 Protein Structure

Zip

Zip: ZIP Zinc transporter (369 - 683)

  • 0
  • 200
  • 400
  • 600
  • 691 a.a.
Protein Preferred Names Protein Names

zinc transporter ZIP12

LIV-1 subfamily of ZIP zinc transporter 8

Related Diseases

Diseases Alias
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13231 SLC39A12 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC39A12 MGD MGI:2139274
Felis catus SLC39A12 VGNC VGNC:65356
Canis familiaris SLC39A12 VGNC VGNC:46401
Rattus norvegicus SLC39A12 RGD RGD:1309305
Bos taurus SLC39A12 VGNC VGNC:34860
Macaca mulatta SLC39A12 VGNC VGNC:77539