Tulp1 - tubby like protein 1 Gene

Also Known as Tulp1l

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22157

Summary

Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in dendrite development; eye photoreceptor cell development; and photoreceptor cell maintenance. Acts upstream of or within phagocytosis, recognition; protein localization to photoreceptor outer segment; and retina development in camera-type eye. Located in several cellular components, including axon terminus; photoreceptor inner segment; and photoreceptor outer segment. Used to study retinitis pigmentosa 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 15; retinitis pigmentosa; and retinitis pigmentosa 14. Orthologous to human TULP1 (TUB like protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tulp1 Products (1)

mRNA	Protein	Name
NM_021478.2	NP_067453.1	tubby-related protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19837063	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in dendrite development	IMP IMP: Inferred from mutant phenotype	19218615	MGI
involved in eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	19218615	MGI
acts upstream of or within phagocytosis, recognition	IDA IDA: Inferred from direct assay	20978472	MGI
acts upstream of or within phagocytosis, recognition	IMP IMP: Inferred from mutant phenotype	19837063	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	10549638	MGI
involved in photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	19218615	MGI
acts upstream of or within protein localization to photoreceptor outer segment	IMP IMP: Inferred from mutant phenotype	11481257	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	10549638	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon terminus	IDA IDA: Inferred from direct assay	11481257	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11481257	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	19695251	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	10549638	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	19218615	MGI
located in synapse	IDA IDA: Inferred from direct assay	19218615	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tubby-related protein 1	tubby like protein 1 like

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15270	TULP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tulp1	NCBI	NCBI:7287