Uba3 - ubiquitin-like modifier activating enzyme 3 Gene

Also Known as Ube1c; A830034N06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22200

Summary

The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display Apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Uba3 Products (5)

mRNA Protein Name
NM_001111106.2 NP_001104576.1 NEDD8-activating enzyme E1 catalytic subunit isoform 2
NM_001301857.1 NP_001288786.1 NEDD8-activating enzyme E1 catalytic subunit isoform 3
NM_001301858.1 NP_001288787.1 NEDD8-activating enzyme E1 catalytic subunit isoform 4
NM_001301859.1 NP_001288788.1 NEDD8-activating enzyme E1 catalytic subunit isoform 5
NM_011666.3 NP_035796.2 NEDD8-activating enzyme E1 catalytic subunit isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NEDD8 activating enzyme activity IDA
IDA: Inferred from direct assay
19245792 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20937703 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within endomitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11696557 MGI
acts upstream of or within mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11696557 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
11696557 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NEDD8-activating enzyme E1 catalytic subunit

  • NEDD8-activating enzyme E1C

  • ubiquitin-activating enzyme 3

  • ubiquitin-activating enzyme E1C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15321 UBA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uba3 NCBI NCBI:9039