Ubr1 - ubiquitin protein ligase E3 component n-recognin 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22222

Summary

Enables ubiquitin-protein transferase activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Part of Proteasome complex and ubiquitin Ligase complex. Is expressed in several structures, including branchial arch; genitourinary system; limb bud; liver; and lung. Used to study Johanson-Blizzard syndrome. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome. Orthologous to human UBR1 (ubiquitin protein Ligase E3 component n-recognin 1). [provided by Alliance of Genome Resources, Apr 2022]

Ubr1 Products (1)

mRNA Protein Name
NM_009461.3 NP_033487.2 E3 ubiquitin-protein ligase UBR1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11689692 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
11689692 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
14585983 MGI
enables ubiquitin-protein transferase activity IGI
IGI: Inferred from genetic interaction
11689692 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
14585983 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
11689692 MGI
involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway IDA
IDA: Inferred from direct assay
19008229 MGI
Cellular Component GO Annotation Evidence References Source
part of proteasome complex IGI
IGI: Inferred from genetic interaction
11689692 MGI
part of ubiquitin ligase complex IGI
IGI: Inferred from genetic interaction
11689692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase UBR1

  • E3 alpha

  • N-recognin-1

  • RING-type E3 ubiquitin transferase UBR1

  • ubiquitin-protein ligase E3-alpha-1

  • ubiquitin-protein ligase E3-alpha-I

  • ubiquitin-protein ligase e3 componen n-recognin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15386 UBR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180976 Arg-PEG1-Tαsyn Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ubr1 NCBI NCBI:197131