LRWD1 - leucine rich repeats and WD repeat domain containing 1 Gene

Also Known as ORCA; CENP-33

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 222229

About LRWD1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,464,984-102,473,168 (from NCBI)

This gene has 9 transcripts (splice variants), 188 orthologues and 1 paralogue. Biased expression in testis (RPKM 101.1) and bone marrow (RPKM 5.9).

Summary

The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

LRWD1 Products (2)

mRNA Protein Name
NM_001317721.2 NP_001304650.1 leucine-rich repeat and WD repeat-containing protein 1 isoform 2
NM_152892.3 NP_690852.1 leucine-rich repeat and WD repeat-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
20932478 GOA
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
21029866 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
21029866 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20932478 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
20932478 GOA
involved in establishment of protein localization to chromatin IDA
IDA: Inferred from direct assay
20932478 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
20932478 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
20813266 GOA
part of nuclear origin of replication recognition complex IDA
IDA: Inferred from direct assay
20932478 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18445686 GOA
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
20932478 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRWD1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (48 - 102)

WD40

WD40: WD domain, G-beta repeat (384 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 647 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and WD repeat-containing protein 1

  • ORC-associated protein

Related Diseases

Diseases Alias
Skin Angiosarcoma

  • Angiosarcoma Of Skin

  • Hemangiosarcoma Of The Skin

  • Haemangiosarcoma Of Skin

  • Lymphangiosarcoma Of Skin

  • Cutaneous Angiosarcoma

  • Malignant Haemangioendothelioma Of Skin
Embryonal Testis Carcinoma

  • Testicular Embryonal Carcinoma

  • Embryonal Carcinoma Of Testis

  • Embryonal Carcinoma Of The Testis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07849 LRWD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRWD1 MGD MGI:1918985
Felis catus LRWD1 VGNC VGNC:63320
Macaca mulatta LRWD1 VGNC VGNC:74332
Bos taurus LRWD1 VGNC VGNC:31048
Rattus norvegicus LRWD1 RGD RGD:1359442
Canis familiaris LRWD1 VGNC VGNC:42835
Others LRWD1 NCBI